trans-HYDROXYLATION OF CYCLOPENT-5-ENE[d]ISOXAZOLINES
Научная публикация
trans-HYDROXYLATION OF CYCLOPENT-5-ENE[d]ISOXAZOLINES
Автор(ы): I. P. Antonevich, S. V. Nesterova
УДК: 542.943.2 : 547.514.4 : 547.786.3
Год издания: 2013
Дата загрузки: 23.09.2015
Загрузил(а): Рогова О. А.

Описание:
The title reaction has been studied as a variant of the cyclopentane ring functionalization of cyclopent-5-ene[d]isoxazolines as the key intermediates in total synthesis of aza- and oxo prostaglandin analogues by nitrileoxides approach. The oxidation, epoxides cleavage and hydrolysis of obtained monoesters and/or acylation lead with good yields to trans-5,6-dihydroxycyclopentanoisoxazolines or their acyl derivatives. The synthesized substances are the intermediates in total synthesis of prostaglandin analogues, as well as perspective biologically active compounds.

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ChemistryTechnology of Organic Substances