SYNTHESIS OF (2-FLUOROPHENYL)- AND (4-FLUOROPHENYL)-(2-NITROMETHYL)-METHANONES AS PRECURSORS OF FLUORINATED PROSTANOIDS
Научная публикация
SYNTHESIS OF (2-FLUOROPHENYL)- AND (4-FLUOROPHENYL)-(2-NITROMETHYL)-METHANONES AS PRECURSORS OF FLUORINATED PROSTANOIDS
Автор(ы): I. P. Antonevich, Ya. M. Katok, S. V. Nesterova
УДК: 547.514.472
Год издания: 2014
Дата загрузки: 03.12.2015
Загрузил(а): Рогова О. А.

Описание:
The synthesis of new fluorinated primary nitrocompounds −(2-fluorophenyl)- and (4-fluorophenyl)-(2-nitromethylcyclopentyl)methanones has been realized by the nitromethane 1,4-addition to 1-acylcyclopentenes, available by the reductive cleavage of corresponding cyclopent-5-en[d]isoxazolines. The obtained nitrocompounds are the precursors of new fluorinated prostaglandin analogues, which could be synthesized via the formation of second prostanoids side chain by nitrile oxides method.

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ChemistryTechnology of Organic Substances