APPLICATION OF FT-IR SPECTROSCOPY FOR DETERMINATION OF CLARITHROMYCIN IN PHARMACEUTICALS
Научная публикация
APPLICATION OF FT-IR SPECTROSCOPY  FOR DETERMINATION OF CLARITHROMYCIN IN PHARMACEUTICALS
Автор(ы): E. S. Likhtarovich, V. G. Lugin
УДК: 543.421/.424:615.2
Год издания: 2014
Дата загрузки: 03.12.2015
Загрузил(а): Рогова О. А.

Описание:
Method for the qualitative and quantitative assessment of clarithromycin – macrolide antibiotic – in pharmaceutical formulations was developed by using Fourier-transform infrared (FT-IR) transmission spectroscopy for quality control. The calibration model was developed based on simple Beer's law using the FT-IR carbonyl region (C=O) from 1,750 to 1,675 cm −1 . Statistical analysis of the results was developed by using TQ Analyst program and based on the least square method. The good coefficient of determination was achieved R 2 = 0.9973. Recovery was achieved from 98 to 106%. The method based on the FT-IR spectroscopy for the quantitative analysis of clarithromycin in pharmaceutical formulations is a fast and promising technique.

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ChemistryTechnology of Organic SubstancesBiotechnology